Product Overview
Ingenol mebutate | TN1047 | TargetMol Chemicals
CAS: 75567-37-2
Smiles: C\C=C(\C)C(=O)O[C@H]1C(C)=C[C@]23[C@H](C)C[C@@H]4[C@H]([C@H](C=C(CO)[C@@H](O)[C@]12O)C3=O)C4(C)C
Formula: C25H34O6
Pathway: Chromatin/Epigenetic|||Cytoskeletal Signaling|||Immunology/Inflammation|||Microbiology/Virology|||Proteases/Proteasome
Target: gp120/CD4|||HIV Protease|||PKC
Receptor: N/A
Bioactivity: Ingenol mebutate shows anticancer activity, and P-gp-mediated absorptive transport, dermal penetration, and vascular damage contribute to the anticancer activity of ingenol-3-angelate in vivo; it activates a broad range of PKC isoforms and induces apoptosis in acute myeloid leukemia cells by activating the PKC isoform PKCdelta.
Molecular Weight: 430, 541
