Product Overview
IQ-3 | T8477 | TargetMol Chemicals
CAS: 312538-03-7
Smiles: O=C(ON=C1c2ccccc2-c2nc3ccccc3nc12)c1ccco1
Formula: C20H11N3O3
Pathway: MAPK
Target: JNK
Receptor: N/A
Bioactivity: IQ3 is a selective inhibitor of JNK3(JNK3, JNK1 and JNK2 with Kd of 66 nM, 240 nM and 290 nM, respectively). IQ 3 inhibits NF-κB/AP1 transcriptional activity in THP1-Blue cells with IC50 of 1.4 μM, also inhibits TNF-α and IL-6 production in vitro.
Molecular Weight: 341, 326
