Product Overview
Isofraxidin | T5S0045 | TargetMol Chemicals
CAS: 486-21-5
Smiles: COc1cc2ccc(=O)oc2c(OC)c1O
Formula: C11H10O5
Pathway: Immunology/Inflammation|||MAPK|||Neuroscience|||Proteases/Proteasome
Target: MMP|||ERK|||p38 MAPK|||TLR|||COX
Receptor: N/A
Bioactivity: 1. Isofraxidin protects leukemia cells from radiation-induced apoptosis via ROS/mitochondria pathway in a p53-independent manner. 2. Isofraxidin has a protective effect against LPS-induced ALI, and the protective effect of Isofraxidin seems to result from the inhibition of COX-2 protein expression in the lung, which regulates the production of PGE2. 3. Isofraxidin possesses significant analgesic and anti-inflammatory activities that may be mediated through the regulation of pro-inflammatory cytokines, TNF-α and the phosphorylation of p38 and ERK1/2.
Molecular Weight: 222, 196