Product Overview
Isorhamnetin | T2836 | TargetMol Chemicals
CAS: 480-19-3
Smiles: COc1cc(ccc1O)-c1oc2cc(O)cc(O)c2c(=O)c1O
Formula: C16H12O7
Pathway: MAPK|||Metabolism|||PI3K/Akt/mTOR signaling
Target: MEK|||PI3K|||Endogenous Metabolite
Receptor: N/A
Bioactivity: Isorhamnetin is the methylated metabolite of quercetin. Quercetin is an important dietary flavonoid with in vitro antioxidant activity. Isorhamnetin prevents endothelial cell injuries from oxidized LDL via inhibition of lectin-like ox-LDL receptor-1 upregulation, interference of ox-LDL-mediated intracellular signaling pathway (p38MAPK activation, NF-kappaB nuclear translocation, eNOS expression) and the antioxidant activity of isorhamnetin. Isorhamnetin prevents endothelial dysfunction, superoxide production, and overexpression of p47phox induced by angiotensin II. Isorhamnetin appears to be a potent drug against esophageal cancer due to it's in vitro potential to not only inhibit proliferation but also induce apoptosis of Eca-109 cells.
Molecular Weight: 316, 265
