Product Overview
Isosilybin A | TN1804 | TargetMol Chemicals
CAS: 142796-21-2
Smiles: COc1cc(ccc1O)[C@H]1Oc2ccc(cc2O[C@@H]1CO)[C@H]1Oc2cc(O)cc(O)c2C(=O)[C@@H]1O
Formula: C25H22O10
Pathway: Apoptosis|||DNA Damage/DNA Repair|||Membrane transporter/Ion channel|||Metabolism|||Proteases/Proteasome
Target: Apoptosis|||Tyrosinase|||PPAR|||ABC
Receptor: N/A
Bioactivity: Isosilybin A is a partial PPARγ agonist, it significantly induced ABCA1 protein expression, it inhibited both monophenolase (IC50=1.7-7.6μM) and diphenolase (IC50=12.1-44.9μM) of tyrosinase. Isosilybin A shows anti-angiogenic efficacy, it has anti-prostate cancer (PCA) activity that is mediated via cell cycle arrest and apoptosis induction.
Molecular Weight: 482, 441
