Product Overview
Isosilybin B | TN1805 | TargetMol Chemicals
CAS: 142796-22-3
Smiles: COc1cc(ccc1O)[C@@H]1Oc2ccc(cc2O[C@H]1CO)[C@H]1Oc2cc(O)cc(O)c2C(=O)[C@@H]1O
Formula: C25H22O10
Pathway: Apoptosis|||Cytoskeletal Signaling|||PI3K/Akt/mTOR signaling
Target: Mdm2|||Akt|||PI3K
Receptor: N/A
Bioactivity: Isosilybin B causes androgen receptor degradation in human prostate carcinoma cells via PI3K-Akt-Mdm2-mediated pathway, it has anti-prostate cancer (PCA) activity that is mediated via cell cycle arrest and apoptosis induction. Isosilybin B showed inhibitory effect on CYP2C8 activity. It inhibited both monophenolase (IC50=1.7-7.6μM) and diphenolase (IC50=12.1-44.9μM) of tyrosinase.
Molecular Weight: 482, 441
