Product Overview
Ivosidenib | T3617 | TargetMol Chemicals
CAS: 1448347-49-6
Smiles: Fc1cncc(c1)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1cc(ccn1)C#N
Formula: C28H22ClF3N6O3
Pathway: Metabolism
Target: Dehydrogenase|||Isocitrate Dehydrogenase (IDH)
Receptor: N/A
Bioactivity: Ivosidenib is an orally available inhibitor of isocitrate dehydrogenase type 1 (IDH1), with potential antineoplastic activity. Ivosidenib specifically inhibits a mutated form of IDH1 in the cytoplasm, which inhibits the formation of the oncometabolite, 2-hydroxyglutarate (2 hG). This may lead to both an induction of cellular differentiation and an inhibition of cellular proliferation in IDH1-expressing tumor cells.
Molecular Weight: 582, 97
