Product Overview
Jaceosidin | T3824 | TargetMol Chemicals
CAS: 18085-97-7
Smiles: COc1cc(ccc1O)-c1cc(=O)c2c(O)c(OC)c(O)cc2o1
Formula: C17H14O7
Pathway: Apoptosis|||Immunology/Inflammation|||Metabolism|||Neuroscience
Target: Apoptosis|||BCL|||COX|||UGT
Receptor: N/A
Bioactivity: Jaceosidin has anti-oxidative activity. Jaceosidin has anti-inflammatory activity, also a microglial inhibitor with anti-neuroinflammation activity. aceosidin has anticancer activity, modulates the ERK/ATM/Chk1/2 pathway, leading to inactivation of the Cdc2-cyclin B1 complex, followed by G2/M cell cycle arrest in endometrial cancer cells. Jaceosidin has immunosuppressive effect through inhibiting T cell proliferation and activation, which is closely associated with its potent down-regulation of the IFN-γ/STAT1/T-bet signaling pathway. The pharmacokinetics of Jaceosidin may be dramatically affected by polymorphic CYP1A2, UGT1A1, and UGT1A7 responsible for the metabolism of Jaceosidin or by the coadministration of relevant CYP1A2 or UGT inhibitors or inducers.
Molecular Weight: 330, 292
