Product Overview
Jervine | T3363 | TargetMol Chemicals
CAS: 469-59-0
Smiles: [H][C@@]12NC[C@@H](C)C[C@H]1O[C@]1(CC[C@]3([H])C(C(=O)[C@@]4([H])[C@@]3([H])CC=C3C[C@@H](O)CC[C@]43C)=C1C)[C@@H]2C
Formula: C27H39NO3
Pathway: GPCR/G Protein|||Stem Cells
Target: Hedgehog/Smoothened|||Smo
Receptor: N/A
Bioactivity: The biological activity of Jervine is mediated via its interaction with the 7 passes transmembrane protein Smoothened. Jervine binds with and inhibits smoothened, which is an integral part of the Hedgehog signaling pathways. With smoothened inhibited, the GLI1 transcription cannot be activated and Hedgehog target genes cannot be transcribed.
Molecular Weight: 425, 613
