Product Overview
JHU37160 | T9018 | TargetMol Chemicals
CAS: 2369979-68-8
Smiles: CCN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c(F)cccc12
Formula: C19H20ClFN4
Pathway: Neuroscience
Target: AChR
Receptor: N/A
Bioactivity: JHU 37160 is a Designer Receptors Exclusively Activated by Designer Drug (DREADD) agonist with Ki of 1.9 nM and 3.6 nM for human muscarinic acetylcholine M3 receptors (hM3Dq) and hM4Di in vitro, respectively. And EC50 values are 18.5 nM and 0.2 nM for hM3Dq and hM4Di in fluorescent and BRET-based assays in HEK-293 cells, respectively.
Molecular Weight: 358, 85