Product Overview
JK-P3 | T4425 | TargetMol Chemicals
CAS: 942655-44-9
Smiles: COc1ccc(cc1OC)C(=O)Nc1cc(n[nH]1)-c1ccccc1
Formula: C18H17N3O3
Pathway: Angiogenesis|||Tyrosine Kinase/Adaptors
Target: VEGFR
Receptor: N/A
Bioactivity: JK-P3 is a pyrazole-based inhibitor of VEGFR-2 (IC50: 7.8 μM). JK-P3 inhibits FGFR 1/3 kinase activity in vitro, but has no effect on FGFR signaling in cell-based assays. The compound blocks wound healing and tube formation in HUVEC without effecting endothelial cell proliferation.
Molecular Weight: 323, 352
