Product Overview
JNJ-10198409 | T15616 | TargetMol Chemicals
CAS: 627518-40-5
Smiles: COc1cc2Cc3c(Nc4cccc(F)c4)n[nH]c3-c2cc1OC
Formula: C18H16FN3O2
Pathway: Angiogenesis|||Tyrosine Kinase/Adaptors
Target: PDGFR
Receptor: N/A
Bioactivity: JNJ- 10198409 is a relatively selective and ATP competitive PDGF-RTK inhibitor (IC50=2 nM). JNJ-10198409 has good activity against PDGFR-β kinase (IC50=4.2 nM) and PDGFR-α kinase (IC50=45 nM). It is a dual-mechanism, antiangiogenic, and tumor cell antiproliferative agent.
Molecular Weight: 325, 343
