Product Overview
JNJ-42165279 | T3215 | TargetMol Chemicals
CAS: 1346528-50-4
Smiles: FC1(F)Oc2ccc(CN3CCN(CC3)C(=O)Nc3cnccc3Cl)cc2O1
Formula: C18H17ClF2N4O3
Pathway: Autophagy|||Metabolism|||Neuroscience
Target: FAAH|||Autophagy
Receptor: N/A
Bioactivity: JNJ-42165279 covalently inactivates the FAAH enzyme but is highly selective with regard to other enzymes, ion channels, transporters, and receptors. JNJ-42165279 (10 μM) exhibits high selectivity against a panel of 50 receptors, enzymes, transporters, and ion-channels, at which concentration it does not produce >50% inhibition of binding to any of the targets. Fortunately, JNJ-42165279 (10 μM) also does not inhibit CYPs (1A2, 2C8, 2C9, 2C19, 2D6, 3A4) or hERG.
Molecular Weight: 410, 81
