Product Overview
JNJ-46281222 | T15618 | TargetMol Chemicals
CAS: 1254980-38-5
Smiles: FC(F)(F)c1c(CN2CCC(CC2)c2ccccc2)ccn2c(CC3CC3)nnc12
Formula: C23H25F3N4
Pathway: Neuroscience
Target: GluR
Receptor: N/A
Bioactivity: JNJ-46281222 is an metabotropic glutamate (mGlu) 2-selective, highly potent PAM (positive allosteric modulator). It has nanomolar affinity (Kd = 1.7 nM) and a high modulatory potency (pEC50 = 7.71).
Molecular Weight: 414, 476
