Product Overview
K-Ras ligand-Linker Conjugate 5 | T18058 | TargetMol Chemicals
CAS: 2378261-85-7
Smiles: CN1C[C@@H](C[C@H]1COc1nc2CN(CCc2c(n1)N1CCN([C@@H](CC#N)C1)C(=O)OC(C)(C)C)c1cccc2ccccc12)OCCOCCOCCOCCO
Formula: C42H59N7O8
Pathway: Others
Target: Others
Receptor: N/A
Bioactivity: K-Ras ligand-Linker Conjugate 5 incorporates a ligand for K-Ras recruiting moiety, and a PROTAC linker, which recruit E3 ligases (such as VHL, CRBN, MDM2, and IAP). K-Ras ligand-Linker Conjugate 5 can be used in the synthesis of PROTAC K-Ras Degrader-1, which is potent PROTAC K-Ras degrader that exhibits ≥70% degradation efficacy in SW1573 cells[1].
Molecular Weight: 789, 975
