Product Overview
K-Ras ligand-Linker Conjugate 6 | T18059 | TargetMol Chemicals
CAS: 2378261-89-1
Smiles: CN1C[C@@H](C[C@H]1COc1nc2CN(CCc2c(n1)N1CCN([C@@H](CC#N)C1)C(=O)OC(C)(C)C)c1cccc2ccccc12)OCCOCCOCCOCCN
Formula: C42H60N8O7
Pathway: Others
Target: Others
Receptor: N/A
Bioactivity: K-Ras ligand-Linker Conjugate 6 incorporates a ligand for K-Ras recruiting moiety, and a PROTAC linker, which recruit E3 ligases (such as VHL, CRBN, MDM2, and IAP). K-Ras ligand-Linker Conjugate 6 can be used in the synthesis of PROTAC K-Ras Degrader-1, which is potent PROTAC K-Ras degrader that exhibits ≥70% degradation efficacy in SW1573 cells[1].
Molecular Weight: 788, 991
