Product Overview
K41498 | TP2009 | TargetMol Chemicals
CAS: 434938-41-7
Smiles:
Formula: C162H276N48O46
Pathway: N/A
Target: N/A
Receptor: N/A
Bioactivity: Potent and highly selective CRF2 receptor antagonist (Ki values are 0.66, 0.62 and 425 nM for human CRF2α, CRF2β and CRF1 receptors respectively). Inhibits sauvagine-stimulated cAMP accumulation in hCRF2α- and hCRF2β-expressing cells. In rats in vivo, blocks urocortin-induced hypotension following systemic administration.
Molecular Weight: 3632, 26
