K777 | T15641

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€100.00
SKU:
TMC-T15641
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Product Overview

K777 | T15641 | TargetMol Chemicals

CAS: 233277-99-1

Smiles: CN1CCN(CC1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCc1ccccc1)\C=C\S(=O)(=O)c1ccccc1

Formula: C32H38N4O4S

Pathway: Proteases/Proteasome

Target: Cysteine Protease

Receptor: N/A

Bioactivity: K777 is an orally active and irreversible cysteine protease inhibitor. K777 is a broad-spectrum antiviral by targeting cathepsin-mediated cell entry. K777 is also a CYP3A4 inhibitor (IC50: 60 nM) and a CCR4 antagonist. K777 inhibits SARS-CoV and EBOV pseudovirus entry (IC50s: 0.68 nM and 0.87 nM). K777 irreversibly inhibits Cruzain, and cathepsins B and L.

Molecular Weight: 574, 74

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