Product Overview
K777 | T15641 | TargetMol Chemicals
CAS: 233277-99-1
Smiles: CN1CCN(CC1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCc1ccccc1)\C=C\S(=O)(=O)c1ccccc1
Formula: C32H38N4O4S
Pathway: Proteases/Proteasome
Target: Cysteine Protease
Receptor: N/A
Bioactivity: K777 is an orally active and irreversible cysteine protease inhibitor. K777 is a broad-spectrum antiviral by targeting cathepsin-mediated cell entry. K777 is also a CYP3A4 inhibitor (IC50: 60 nM) and a CCR4 antagonist. K777 inhibits SARS-CoV and EBOV pseudovirus entry (IC50s: 0.68 nM and 0.87 nM). K777 irreversibly inhibits Cruzain, and cathepsins B and L.
Molecular Weight: 574, 74