Product Overview
KAG-308 | T15642 | TargetMol Chemicals
CAS: 1215192-68-9
Smiles: [H][C@]12C[C@@H](O)[C@H](\C=C\[C@@H](O)[C@H](C)c3cccc(C)c3)[C@@]1([H])C(F)(F)\C(O2)=C\CCCc1nnn[nH]1
Formula: C24H30F2N4O3
Pathway: GPCR/G Protein|||Immunology/Inflammation
Target: Prostaglandin Receptor
Receptor: N/A
Bioactivity: KAG-308 is an effective selective and orally active agonist of the EP4 receptor (Ki: 2.57 nM and EC50: 17 nM for human EP4 receptor), more selective over EP1, EP2, EP3, and IP receptor. KAG-308 suppresses colitis and promotes histological mucosal healing, which potently inhibits TNF-α production.
Molecular Weight: 460, 526
