KB02-SLF | T18061

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TMC-T18061
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Product Overview

KB02-SLF | T18061 | TargetMol Chemicals

CAS: T18061

Smiles: O=C([C@H]1N(C(C(C(C)(C)CC)=O)=O)CCCC1)O[C@@H](C2=CC=CC(NC(CCOCCOCCNC(COC3=CC4=C(N(C(CCl)=O)CCC4)C=C3)=O)=O)=C2)CCC5=CC=C(OC)C(OC)=C5

Formula: C50H65ClN4O12

Pathway: Others

Target: Others

Receptor: N/A

Bioactivity: KB02-SLF is a PROTAC-based nuclear FKBP12 degrader (molecular glue). KB02-SLF promotes nuclear FKBP12 degradation by covalently modifying DCAF16 (E3 ligase) and can improve the durability of protein degradation in biological systems. SLF binds ubiquitin E3 ligase ligand KB02 via a linker to form KB02-SLF[1].

Molecular Weight: 949, 52

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