Product Overview
KG5 | T41003 | TargetMol Chemicals
CAS: 877874-85-6
Smiles: FC(F)(F)C=1C=CC=C(C1)NC2=NN=C(N2)C=3C=CC(OC4=NC(=NC(N)=C4)SC)=CC3
Formula: C20H16F3N7OS
Pathway: Angiogenesis|||MAPK|||Tyrosine Kinase/Adaptors
Target: Raf|||FLT|||PDGFR|||c-Kit
Receptor: N/A
Bioactivity: KG5 is a dual allosteric inhibitor of PDGFRβ and B-Raf with a Kd of 520 nM and 300 nM for PDGFRβ and PDGFRα. KG5 inhibits FLT3, KIT, and c-Raf with anticancer and antiangiogenic activities.
Molecular Weight: 459, 45