Product Overview
KL001 | T22891 | TargetMol Chemicals
CAS: 309928-48-1
Smiles: CS(=O)(=O)N(CC(O)Cn1c2ccccc2c2ccccc12)Cc1ccco1
Formula: C21H22N2O4S
Pathway: Others
Target: Others
Receptor: N/A
Bioactivity: KL 001 is a Cryptochrome protein (CRY) stabilizer. KL001 prevented ubiquitin-dependent degradation of CRY, resulting in lengthening of the circadian period. KL001-mediated CRY stabilization inhibited glucagon-induced gluconeogenesis in primary hepatocytes. KL001 thus provides a tool to study the regulation of CRY-dependent physiology and aid development of clock-based therapeutics of diabetes.
Molecular Weight: 398, 48