Product Overview
KL1333 | T16342 | TargetMol Chemicals
CAS: 1800405-30-4
Smiles: CC(C)c1nc-2c([nH]1)C(=O)C(=O)c1ccccc-21
Formula: C14H12N2O2
Pathway: Metabolism
Target: NADPH|||Mitochondrial Metabolism
Receptor: N/A
Bioactivity: KL1333 enhances energy metabolism and mitochondrial dysfunction in MELAS fibroblasts. Elevated NAD+ levels trigger the activation of SIRT1 and AMPK, and subsequently activates PGC-1α. NQO1 activator 1 is an orally available NAD+ modulator. It reacts with NAD(P)H: NQO1 as a substrate, resulting in increases in intracellular NAD+ levels via NADH oxidation.
Molecular Weight: 240, 262