KML29 | T4052

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€175.00 - €969.00
SKU:
TMC-T4052
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Product Overview

KML29 | T4052 | TargetMol Chemicals

CAS: 1380424-42-9

Smiles: OC(C1CCN(CC1)C(=O)OC(C(F)(F)F)C(F)(F)F)(c1ccc2OCOc2c1)c1ccc2OCOc2c1

Formula: C24H21F6NO7

Pathway: Metabolism

Target: Lipase

Receptor: N/A

Bioactivity: KML29 is highly selective and effective monoacylglycerol lipase (MAGL) inhibitor. It has effective inhibition of human/mouse/rat MAGL (IC50: 5.9/15/43 nM). It has not inhibitory for FAAH (IC50 > 50 μM). It also effectively and selectively blocks hydrolysis of 2-arachidonoylglycerol (2-AG) in mice (IC50: 2.5 nM, 2-AG; >50 μM, AEA).

Molecular Weight: 549, 422

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