Product Overview
Kobe0065 | T1876 | TargetMol Chemicals
CAS: 436133-68-5
Smiles: Cc1ccc(NC(=S)NNc2c(cc(cc2[N+]([O-])=O)C(F)(F)F)[N+]([O-])=O)cc1Cl
Formula: C15H11ClF3N5O4S
Pathway: Apoptosis|||GPCR/G Protein|||MAPK
Target: Apoptosis|||Raf|||Ras
Receptor: N/A
Bioactivity: Kobe0065 is a novel and effective small-molecule compound inhibiting Ras–Raf interaction by SBDD; shows potent activity to competitively inhibit the binding of H-Ras·GTP to c-Raf-1 RBD with a Ki value of 46 ± 13 μM.
Molecular Weight: 449, 79
