Product Overview
KW-2449 | T2341 | TargetMol Chemicals
CAS: 1000669-72-6
Smiles: O=C(N1CCNCC1)c1ccc(\C=C\c2n[nH]c3ccccc23)cc1
Formula: C20H20N4O
Pathway: Angiogenesis|||Apoptosis|||Cell Cycle/Checkpoint|||Chromatin/Epigenetic|||Cytoskeletal Signaling|||JAK/STAT signaling|||Stem Cells|||Tyrosine Kinase/Adaptors
Target: Apoptosis|||FGFR|||FLT|||JAK|||Bcr-Abl|||Src|||c-Kit|||Aurora Kinase
Receptor: N/A
Bioactivity: KW-2449 is a multiple-targeted inhibitor, mostly for Flt3 (IC50: 6.6 nM), modestly effective to Bcr-Abl, FGFR1, and Aurora A; little inhibitory on PDGFRβ, IGF-1R, EGFR.
Molecular Weight: 332, 407
