Product Overview
Leriglitazone | T15736 | TargetMol Chemicals
CAS: 146062-44-4
Smiles: CC(O)c1ccc(CCOc2ccc(CC3SC(=O)NC3=O)cc2)nc1
Formula: C19H20N2O4S
Pathway: Others
Target: Others
Receptor: N/A
Bioactivity: Leriglitazone, a metabolite of pioglitazone, binds to the PPARγ C-terminal ligand-binding domain (Ki: 1.2 μM) and induces transcriptional efficacy of the PPARγ (EC50: 680 nM). Leriglitazone PioOH is a PPARγ agonist, stabilizes the PPARγ activation function-2 (AF-2) co-activator binding surface.
Molecular Weight: 372, 44