Product Overview
Lexibulin | T2090 | TargetMol Chemicals
CAS: 917111-44-5
Smiles: CCC[C@H](Nc1nc(ncc1C)-c1ccc(NC(=O)NCC)c(OC)c1)c1cccnc1
Formula: C24H30N6O2
Pathway: Apoptosis|||Cytoskeletal Signaling|||Immunology/Inflammation|||Metabolism|||NF-Κb
Target: Apoptosis|||Reactive Oxygen Species|||Microtubule Associated
Receptor: N/A
Bioactivity: Lexibulin(CYT-997) is a potent tubulin polymerization inhibitor (IC50: 10-100 nM, in Y cell lines). Lexibulin blocks the formation of the mitotic spindle and leading to cell cycle arrest at the G2/M phase; this may result in disruption of the tumor vasculature and tumor blood flow, and tumor cell death.
Molecular Weight: 434, 544
