Product Overview
LGK974 | T2618 | TargetMol Chemicals
CAS: 1243244-14-5
Smiles: Cc1cc(ccn1)-c1ncc(CC(=O)Nc2ccc(cn2)-c2cnccn2)cc1C
Formula: C23H20N6O
Pathway: Stem Cells
Target: Porcupine
Receptor: N/A
Bioactivity: LGK-974 is an effective and selective PORCN inhibitor and inhibits Wnt signaling (IC50: 0.4 nM) in TM3 cells. It has been used in trials studying the treatment of Metastatic Colorectal Cancer and Squamous Cell Carcinoma, Head And Neck.
Molecular Weight: 396, 454
