Product Overview
Lifirafenib | T22272 | TargetMol Chemicals
CAS: 1446090-79-4
Smiles: O=C1Nc2nccc(Oc(cc3)cc(C45)c3OC4C5c3nc(ccc(C(F)(F)F)c4)c4[nH]3)c2CC1
Formula: C25H17F3N4O3
Pathway: Angiogenesis|||JAK/STAT signaling|||MAPK|||Tyrosine Kinase/Adaptors
Target: EGFR|||Raf
Receptor: N/A
Bioactivity: Lifirafenib is a potent inhibitor of RAF family kinases and EGFR in biochemical assays with IC50 of 23, 29 and 495 nM for the recombinant BRAFV600E kinase domain, EGFR and EGFR T790M/L858R mutant respectively.
Molecular Weight: 478, 42