Product Overview
Linifanib | T2514 | TargetMol Chemicals
CAS: 796967-16-3
Smiles: Cc1ccc(F)c(NC(=O)Nc2ccc(cc2)-c2cccc3[nH]nc(N)c23)c1
Formula: C21H18FN5O
Pathway: Angiogenesis|||Apoptosis|||Autophagy|||Tyrosine Kinase/Adaptors
Target: Apoptosis|||c-Fms|||VEGFR|||FLT|||CSF-1R|||PDGFR|||c-Kit|||Autophagy
Receptor: N/A
Bioactivity: Linifanib (ABT-869) is a novel, potent ATP-competitive VEGFR/PDGFR inhibitor for KDR (IC50: 4 nM), CSF-1R (IC50: 3 nM), Flt-1/3 (IC50: 3/4 nM) and PDGFRβ (IC50: 66 nM). Linifanib may exhibit potent antiproliferative and apoptotic effects on tumor cells whose proliferation is dependent on mutant kinases, such as FMS-related tyrosine kinase receptor-3 (FLT3).
Molecular Weight: 375, 407
