Product Overview
Linsitinib | T6017 | TargetMol Chemicals
CAS: 867160-71-2
Smiles: C[C@@]1(O)C[C@@H](C1)c1nc(-c2ccc3ccc(nc3c2)-c2ccccc2)c2c(N)nccn12
Formula: C26H23N5O
Pathway: Others|||Tyrosine Kinase/Adaptors
Target: Others|||IGF-1R
Receptor: N/A
Bioactivity: OSI-906 (Linsitinib) is an orally bioavailable small molecule inhibitor of the insulin-like growth factor 1 receptor (IGF-1R) with potential antineoplastic activity. Linsitinib selectively inhibits IGF-1R, which may result in the inhibition of tumor cell proliferation and the induction of tumor cell apoptosis. Overexpressed in a variety of human cancers, IGF-1R stimulates cell proliferation, enables oncogenic transformation, and suppresses apoptosis.
Molecular Weight: 421, 504
