Product Overview
Lofepramine | T15773 | TargetMol Chemicals
CAS: 23047-25-8
Smiles: CN(CCCN1c2ccccc2CCc2ccccc12)CC(=O)c1ccc(Cl)cc1
Formula: C26H27ClN2O
Pathway: GPCR/G Protein|||Neuroscience
Target: 5-HT Receptor|||Norepinephrine
Receptor: N/A
Bioactivity: Lofepramine is a potent tricyclic antidepressant that is extensively metabolized to desipramine. It inhibits the serotonin and norepinephrine transporters by inhibiting neurons with Kd values of 70 and 5.4 nM, respectively, with weak antagonism of serotonin, histamine and muscarinic receptors.
Molecular Weight: 418, 97
