Product Overview
Losartan Carboxylic Acid | T3461 | TargetMol Chemicals
CAS: 124750-92-1
Smiles: CCCCc1nc(Cl)c(C(O)=O)n1Cc1ccc(cc1)-c1ccccc1-c1nn[nH]n1
Formula: C22H21ClN6O2
Pathway: Endocrinology/Hormones
Target: RAAS
Receptor: N/A
Bioactivity: EXP-3174 is a potent AT1 antagonist (Kis: 0.57 nM, rat; 0.67 nM, human), producing a depressor response and vasodilatation. EXP3174, a metabolite of losartan, is more potent than losartan in blocking the angiotensin II-induced responses in vascular smooth muscle cells.
Molecular Weight: 436, 9
