Product Overview
Loureirin A | T5S0896 | TargetMol Chemicals
CAS: 119425-89-7
Smiles: COc1ccc(CCC(=O)c2ccc(O)cc2)c(OC)c1
Formula: C17H18O4
Pathway: Cytoskeletal Signaling|||PI3K/Akt/mTOR signaling
Target: Akt|||PI3K
Receptor: N/A
Bioactivity: Loureirin A has an inhibitory effect on platelet activation, perhaps through an impairment of PI3K/Akt signaling.Loureirin A negatively affects agonist-induced platelet aggregation such as collagen, collagen-related peptide (CRP), ADP and thrombin. Loureirin A activates Wnt/-catenin pathway and promotes hair follicle stem cells (FSCs)-seeded tissue-engineered skin to repair skin wound.The molecular mechanism of Loureirin A and Wnt signaling pathway mediated anti- hepatic fibrosis and anti- angiogenesis may involve down- regulation the expression of Frizzled- 4, inhibiting the synthesis and secretion of α- SMA, TGF- β1and the proliferation of HSCs.
Molecular Weight: 286, 327
