Product Overview
LY2811376 | T2639 | TargetMol Chemicals
CAS: 1194044-20-6
Smiles: S1C(=N[C@](CC1)(C)c1c(cc(c(c1)c1cncnc1)F)F)N
Formula: C15H14F2N4S
Pathway: Neuroscience
Target: Beta Amyloid|||Beta-Secretase|||BACE
Receptor: N/A
Bioactivity: LY2811376, an orally available non-peptidic β-secretase(BACE1) inhibitor (IC50: 239-249 nM), can decrease Aβ secretion (EC50: 300 nM). It has 10-fold selectivity towards BACE1 over BACE2, and more than 50-fold inhibition over other aspartic proteases including pepsin, cathepsin D, or renin.
Molecular Weight: 320, 36
