Product Overview
Lys05 | T3437 | TargetMol Chemicals
CAS: 1391426-24-6
Smiles: Cl.Cl.Cl.CN(CCNc1ccnc2cc(Cl)ccc12)CCNc1ccnc2cc(Cl)ccc12
Formula: C23H26Cl5N5
Pathway: Autophagy
Target: lysosomal autophagy|||Autophagy
Receptor: N/A
Bioactivity: Lys05, or Lys01 trihydrochloride, is a potent, water soluble lysosomal autophagy inhibitor. Lys05 is a previously undescribed dimeric chloroquine which more potently accumulates in the lysosome and blocks autophagy compared with HCQ. Lys05 produced more potent antitumor activity as a single agent both in vitro and in vivo in multiple human cancer cell lines and xenograft models compared with HCQ. Lys05 is therefore a new lysosomal autophagy inhibitor that has potential to be developed further into a drug for cancer and other medical applications.
Molecular Weight: 549, 75
