Product Overview
M62812 | T37292 | TargetMol Chemicals
CAS: 613263-00-6
Smiles: Cl.Cl.Nc1nsc2cc(Oc3ccccc3N)ccc12
Formula: C13H13Cl2N3OS
Pathway: Immunology/Inflammation
Target: TLR
Receptor: N/A
Bioactivity: TLR4 inhibitor. Inhibits LPS-induced NF-κB activation in HEK293 cells (IC50 = 2.4 μg/mL). Also inhibits LPS-induced cytokine production and procoagulant effects in PBMCs and HUVECs. Prolongs survival in a mouse septic shock model.
Molecular Weight: 330, 23