M62812 | T37292

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€233.00 - €2,799.00
SKU:
TMC-T37292
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Product Overview

M62812 | T37292 | TargetMol Chemicals

CAS: 613263-00-6

Smiles: Cl.Cl.Nc1nsc2cc(Oc3ccccc3N)ccc12

Formula: C13H13Cl2N3OS

Pathway: Immunology/Inflammation

Target: TLR

Receptor: N/A

Bioactivity: TLR4 inhibitor. Inhibits LPS-induced NF-κB activation in HEK293 cells (IC50 = 2.4 μg/mL). Also inhibits LPS-induced cytokine production and procoagulant effects in PBMCs and HUVECs. Prolongs survival in a mouse septic shock model.

Molecular Weight: 330, 23

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