Product Overview
Manumycin A | T16011 | TargetMol Chemicals
CAS: 52665-74-4
Smiles: [H][C@]12O[C@@]1([H])[C@](O)(\C=C\C=C\C=C\C(=O)NC1=C(O)CCC1=O)C=C(NC(=O)C(\C)=C\C(\C)=C\[C@H](C)CCCC)C2=O
Formula: C31H38N2O7
Pathway: GPCR/G Protein|||Immunology/Inflammation
Target: Prostaglandin Receptor
Receptor: N/A
Bioactivity: Manumycin A is an antibiotic. Manumycin A induces apoptosis and exerts antitumor activity. Manumycin A inhibits exosome biogenesis and secretion via targeted inhibition of Ras/Raf/ERK1/2 signaling. Manumycin A acts as a selective, competitive inhibitor of protein farnesyltransferase (FTase) with respect to farnesylpyrophosphate (Ki =1.2 μM), and as a noncompetitive inhibitor with respect to the Ras protein.
Molecular Weight: 550, 652
