Product Overview
Mardepodect | T16499 | TargetMol Chemicals
CAS: 898562-94-2
Smiles: CN(N=C1C2=CC=C(OCC3=NC4=CC=CC=C4C=C3)C=C2)C=C1C5=CC=NC=C5
Formula: C25H20N4O
Pathway: Metabolism
Target: PDE
Receptor: N/A
Bioactivity: Mardepodect is a phosphodiesterase inhibitor selective for the PDE10A subtype with an IC50 of 0.37 nM, >1000-fold selectivity over PDE. It is potentially useful for the treatment of schizophrenia. Phosphodiesterase 10A (PDE10A) is highly expressed in striatal medium spiny neurons of both the direct and indirect output pathways. Mardepodect can cross the blood-brain barrier.
Molecular Weight: 392, 45
