Product Overview
Marizomib | T16012 | TargetMol Chemicals
CAS: 437742-34-2
Smiles: C[C@@]12OC(=O)[C@@]1(NC(=O)[C@@H]2CCCl)[C@@H](O)[C@H]1CCCC=C1
Formula: C15H20ClNO4
Pathway: Others
Target: Others
Receptor: N/A
Bioactivity: Marizomib suppresses the CT-L (β5), CT-T-laspase-like (C-L, β1), and trypsin-like (T-L, β2) activities of the 20S proteasome (IC50=3.5, 28, and 430 nM, respectively). Marizomib is a second-generation, irreversible, brain-penetrant inhibitor of pan-proteasome.
Molecular Weight: 313, 78
