Product Overview
Merbarone | T28017 | TargetMol Chemicals
CAS: 97534-21-9
Smiles: O=CN(C1C(=O)NC(=S)NC1=O)c1ccccc1
Formula: C11H9N3O3S
Pathway: N/A
Target: N/A
Receptor: N/A
Bioactivity: Merbarone is a Type II DNA topoisomerase inhibitor. Merbarone inhibits the catalytic activity of human topoisomerase IIalpha by blocking DNA cleavage. Merbarone induces activation of caspase-activated DNase and excision of chromosomal DNA loops from the nuclear matrix. Merbarone induces apoptosis in CEM cells through activation of ICE/CED-3-like protease.
Molecular Weight: 263, 27