Product Overview
Merestinib dihydrochloride | T15808 | TargetMol Chemicals
CAS: 1206801-37-7
Smiles: Cl.Cl.Cc1ccc(C(=O)Nc2ccc(Oc3cc4cnn(C)c4cc3-c3cn[nH]c3)c(F)c2)c(=O)n1-c1ccc(F)cc1
Formula: C30H24Cl2F2N6O3
Pathway: Cell Cycle/Checkpoint|||Cytoskeletal Signaling|||Stem Cells
Target: ROCK
Receptor: N/A
Bioactivity: Merestinib dihydrochloride is an effective and orally bioavailable c-Met inhibitor (Ki=2 nM). It has anti-tumor activities and also has potent activity against MST1R (IC50=11 nM), FLT3 (IC50=7 nM), AXL (IC50=2 nM), MERTK (IC50=10 nM), TEK (IC50=63 nM), ROS1, DDR1/2 (IC50=0.1/7 nM) and MKNK1/2 (IC50=7 nM).
Molecular Weight: 625, 46
