Metoclopramide | T4616

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TMC-T4616
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Product Overview

Metoclopramide | T4616 | TargetMol Chemicals

CAS: 364-62-5

Smiles: CCN(CC)CCNC(=O)c1cc(Cl)c(N)cc1OC

Formula: C14H22ClN3O2

Pathway: GPCR/G Protein|||Neuroscience

Target: Dopamine Receptor|||5-HT Receptor

Receptor: N/A

Bioactivity: Metoclopramide is a dopamine D2 antagonist which has been used for treatment of a variety of gastrointestinal symptoms over the last thirty years. In various countries, metoclopramide is the antiemetic drug of choice in pregnant women. Findings provide reassurance regarding the safety of metoclopramide for the fetus when the drug is given to women to relieve nausea and vomiting during pregnancy. Evidence also supports its use for gastroparesis (poor stomach emptying) and gastroesophageal reflux disease. It appears to bind to dopamine D2 receptors where it is a receptor antagonist, and is also a mixed 5-HT3 receptor antagonist/ 5-HT4 receptor agonist.

Molecular Weight: 299, 8

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