Product Overview
Mitoxantrone | T6588 | TargetMol Chemicals
CAS: 65271-80-9
Smiles: OCCNCCNc1ccc(NCCNCCO)c2C(=O)c3c(O)ccc(O)c3C(=O)c12
Formula: C22H28N4O6
Pathway: Chromatin/Epigenetic|||Cytoskeletal Signaling|||DNA Damage/DNA Repair
Target: Topoisomerase|||PKC
Receptor: N/A
Bioactivity: Mitoxantrone is an anthracenedione antibiotic with antineoplastic activity. Mitoxantrone intercalates into and crosslinks DNA, thereby disrupting DNA and RNA replication. This agent also binds to topoisomerase II, resulting in DNA strand breaks and inhibition of DNA repair. Mitoxantrone is less cardiotoxic compared to doxorubicin.
Molecular Weight: 444, 488
