Product Overview
Mivebresib | T3712 | TargetMol Chemicals
CAS: 1445993-26-9
Smiles: CCS(=O)(=O)Nc1ccc(Oc2ccc(F)cc2F)c(c1)-c1cn(C)c(=O)c2[nH]ccc12
Formula: C22H19F2N3O4S
Pathway: Apoptosis|||Chromatin/Epigenetic
Target: Apoptosis|||Epigenetic Reader Domain
Receptor: N/A
Bioactivity: Mivebresib, also known as ABBV-075, is a potent BET inhibitor (bromodomain (BRD)-containing protein) with potential antineoplastic activity. Upon administration, the bromodomain inhibitor ABBV-075 binds to the acetyl-lysine binding site in the BRD of certain BRD-containing protein(s), thereby preventing the interaction between those proteins and acetylated histones. This disrupts chromatin remodeling, prevents the expression of certain growth-promoting genes, and leads to an inhibition of cell growth in susceptible tumors. Also a potent inhibitor of MYC and the TMPRSS2-ETS fusion proteins.
Molecular Weight: 459, 47