Product Overview
ML 23 | T33450 | TargetMol Chemicals
CAS: 108929-03-9
Smiles: COc1ccc2[nH]cc(CCNc3cc(cc(c3)[N+]([O-])=O)[N+]([O-])=O)c2c1
Formula: C17H16N4O5
Pathway: N/A
Target: N/A
Receptor: N/A
Bioactivity: ML 23 is a melatonin analogue in the treatment and management of Parkinson's disease. ML-23 is a potential clinical candidate for the treatment of PD, and the present study has been undertaken to determine the efficacy of ML-23 in the 1-methyl-4-phenyl, 1, 2, 3, 6 tetrahydropyridine (MPTP) model in the common marmoset. On all parameters, ML-23 produced a significant remission from MPTP-induced Parkinsonism, and this effect did not abate when ML-23 treatment was withdrawn. Conversely, a recurrence of Parkinsonian signs was not observed when ML-23 treatment was withdrawn and substituted with oral vehicle.
Molecular Weight: 356, 338
