Product Overview
ML-323 | T1757 | TargetMol Chemicals
CAS: 1572414-83-5
Smiles: CC(C)c1ccccc1-c1ncc(C)c(NCc2ccc(cc2)-n2ccnn2)n1
Formula: C23H24N6
Pathway: Cell Cycle/Checkpoint|||DNA Damage/DNA Repair|||Ubiquitination
Target: DUB
Receptor: N/A
Bioactivity: ML323 is a reversible and effective USP1-UAF1 inhibitor in a Ub-Rho assay (IC50: 76 nM) and in orthogonal gel-based assays using K63-linked diubiquitin (di-Ub) (IC50: 174 nM 820 nM)and monoubiquitinated PCNA (Ub-PCNA) (IC50: 820 nM) as substrates, respectively.
Molecular Weight: 384, 487
