Product Overview
ML-792 | T16102 | TargetMol Chemicals
CAS: 1644342-14-2
Smiles: NS(=O)(=O)OC[C@H]1C[C@H](C[C@@H]1O)Nc1ncncc1C(=O)c1ccn(Cc2cccc(Br)c2)n1
Formula: C21H23BrN6O5S
Pathway: Ubiquitination
Target: E1/E2/E3 Enzyme
Receptor: N/A
Bioactivity: ML-792 is a specific small ubiquitin-like modifier (SUMO)-activating enzyme (SAE) inhibitor. Compared with NAE/NEDD8 and UAE/ubiquitin (IC50s of 32 μM and >100 μM, respectively), ML-792 is an effective and selective inhibitor of SAE/SUMO1 and SAE/SUMO2 in enzymatic assays (IC50s of 3 and 11 nM, respectively).
Molecular Weight: 551, 42
