Product Overview
ML162 | T8970 | TargetMol Chemicals
CAS: 1035072-16-2
Smiles: COc1ccc(cc1Cl)N(C(C(=O)NCCc1ccccc1)c1cccs1)C(=O)CCl
Formula: C23H22Cl2N2O3S
Pathway: Apoptosis|||Cell Cycle/Checkpoint|||Metabolism|||oxidation-reduction
Target: Ferroptosis|||GPX|||Glutathione Peroxidase
Receptor: N/A
Bioactivity: ML162 is an inhibitor of GPX4 that is selectively lethal to mutant RAS oncogene-expressing cell lines (IC50s = 25 and 578 nM for HRASG12V-expressing and wild-type BJ fibroblasts, respectively)
Molecular Weight: 477, 4